Prolonged use of melatonin for the treatment of insomnia was associated with an increased risk for heart failure, hospitalization, and/or all-cause mortality, an observational study showed.

Individuals with insomnia taking melatonin for a year or more had an 89% higher chance of… pic.twitter.com/OTUHPpohn0

— Medscape (@Medscape) November 10, 2025